Research » StemRegen Papers

• Adult and late foetal equine tendon contain cell populations with weak progenitor properties in comparison to bone marrow derived mesenchymal stem cells

  Strassburg S, Smith RK, Goodship AE, Hardingham TE, Clegg PD - Proceedings of the 52nd Orthopaedic Research Society (2006)

• American College of Veterinary Surgeons Abstract on surgical tendon model

  Little D et al - Vet Surg (2006)

• Anabolic effects of acellular bone marrow, platelet rich plasma, and serum on equine ligament fibroblasts in vitro

  Smith JJ, Scott CM, Ross MW, Smith RKW - Vet Surg (2003), 32, 496

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• Application of a Hall-effect transducer for the measurement of tendon strain in horses

  Stephens PR, Nunamaker DM, Butterweck DM - Am J Vet Res 50 (1989), 1089

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• Autologous mesenchymal stem cell-mediated repair of tendon

  HA, Butler DL, Boivin GP, Smith FN, Malaviya P, Huibregtse B, Caplan AI - Tissue Eng 5(3) (1999), 267-77

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• Cell growth characteristics and differentiation frequency of adherent equine bone marrow derived mesenchymal stromal cells: adipogenic and osteogenic capacity

  Vidal MA, Kilroy GE, Johnson JR, Lopez MJ, Moore RM, Gimble JM - Vet Surg 35(7) (2006), 601-10

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• Chondrocytic differentiation of mesenchymal stem cells sequentially exposed to transforming growth factor-beta1 in monolayer and insulin-like growth factor-I in a three-dimensional matrix

  Worster AA, Brower-Toland BD, Fortier LA, Bent SJ, Williams J, Nixon AJ - J Orthop Res 19(4) (2001), 738-49

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• Combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells in canine hearts for ischemic cardiomyopathy

  Memon IA, Sawa Y, Miyagawa S, Taketani S, Matsuda H - J Thorac Cardiovasc Surg 130(3) (2005), 646-53

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• Derivation, maintenance, and induction of the differentiation in vitro of equine embryonic stem cells

  Saito S, Sawai K, Minamihashi A, Ugai H, Murata T, Yokoyama KK - Methods Mol Biol 329 (2006), 59-79

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• Do adipose tissue-derived mesenchymal stem cells have the same osteogenic and chondrogenic potential as bone marrow-derived cells?

  Im GI, Shin YW, Lee KB - Osteoarthritis and Cartilage 13(10) (2005), 845-53

• Effect of transforming growth factor beta1 on chondrogenic differentiation of cultured equine mesenchymal stem cells

  Worster AA, Nixon AJ, Brower-Toland BD, Williams J - Am J Vet Res 61(9) (2000), 1003-10

• Epidemiological studies into orthopaedic conditions of the equine athlete

  Pickersgill, C - MVM Thesis (2000), University of Glasgow, U.K.

• Equine peripheral blood-derived progenitors in comparison to bone marrow-derived mesenchymal stem cells

  Koerner J, Nesic D, Romero JD, Brehm W, Mainil-Varlet P, Grogan SP - Stem Cells 24(6) (2006), 1613-9

• Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property

  Salingcarnboriboon R, Yoshitake H, Tsuji K, Obinata M, Amagasa T, Nifuji A, Noda M - Exptal cell res 287 (2003), 289-300

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• Extracellular matrix cues for mesenchymal stem cell differentiation

  Richardson LE; Dudhia J; Sadler CJ, Goodship AE, Smith RKW - Proceedings of the 53rd Orthopaedic Research Society, 472 (2007)

• Extracellular matrix scaffolds are repopulated by bone marrow-derived cells in a mouse model of Achilles tendon reconstruction

  Zantop, T., Gilbert, T.W., Yoder, M.C. and Badylak, S.F - J Orthop Res 24 (2006), 1299-1309

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• GFP chimeric models exhibited a biphasic pattern of mesenchymal cell invasion in tendon healing

  Kajikawa Y, Morihara T, Watanabe N, Sakamoto H, Matsuda K, Kobayashi M, Oshima Y, Yoshida A, Kawata M, Kubo T - J Cell Physiol 210(3) (2007), 684-91

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• Harnessing the stem cell for the treatment of tendon injuries: heralding a new dawn?

  Smith RK, Webbon PM - Br J Sports Med 39 (2005), 582-584

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• Horse embryonic stem cell lines from the proliferation of inner cell mass cells

  Li X, Zhou SG, Imreh MP, Ahrlund-Richter L, Allen WR - Stem Cells Dev 15(4) (2006), 523-31

• Horses damp the spring in their step

  Wilson AM, McGuigan MP, Su A, van Den Bogart AJ - Nature 414 (2001), 895

• Isolated fibrillar damage in tendons stimulates local collagenase mRNA expression and protein synthesis

  Lavagnino, M. Arnoczky, S.P. Egerbacher, M. Gardner, K.L. and Burns,M.E - J. Biomech 39(13) (2005), 2355-62

• Medical management of superficial digital flexor tendinitis: A comparative study in 219 horses (1992-2000)

  Dyson SJ - Equine Vet J 36(2004), 415

• Mesenchymal stem cell therapy in equine musculoskeletal disease: science, fact or clinical fiction?

  Taylor SE, Smith RK, Clegg PD - Equine Vet J. 39 (2007), 172-180

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• Mesenchymal stem cell treatment of suspensory ligament branch desmitis: post mortem findings in a 10 year old Russian Warmblood gelding - a case report

  Mountford DR, Smith RKW, Patterson-Kane JC - Pferdeheilkunde 22 (5) (2006), 559-563

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• Mesenchymal stem cells and bone regeneration

  Kraus, KH and Kirker-Head C - Vet Surg 35 (2006), 232-242

• Mesenchymal stem cells as trophic mediators

  Caplan AI, Dennis JE - J Cell Biochem 98(5) (2006), 1076-84

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• Multilineage mesenchymal differentiation potential of human trabecular bone derived cells

  Noth, U., Osyczka, A.M., Tuli, R., Hickok, N.J., Danielson, K.G. and Tuan, R.S - J Orthop Res 20 (2002), 1060-1069

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• Neotendon formation induced by manipulation of the Smad8 signalling pathway in mesenchymal stem cells

  Hoffmann A, Pelled G, Turgeman G, Eberle P, Zilberman Y, Shinar H, Keinan-Adamsky K, Winkel A, Shahab S, Navon G, Gross G, Gazit D - J Clin Invest. 116(4) (2006), 940-52

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• Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes

  Barbero A, Ploegert S, Heberer M, Martin I - Arthritis Rheum 48 (2003), 1315-1325

• Repair of superficial osteochondral defects with an autologous scaffold-free cartilage construct in a caprine model: implantation method and short-term results

  Brehm W, Aklin B, Yamashita T, Rieser F, Trub T, Jakob RP, Mainil-Varlet P - Osteoarthritis and Cartilage 14(12) (2006), 1214-26

• Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes

  Shukunami C, Takimoto A, Oro M, Hiraki Y - Dev Biol 298(1) (2006), 234-47

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• Should equine athletes commence training during skeletal development? Changes in tendon matrix associated with development, ageing, function and exercise

  Smith RKW, Birch HL, Patterson-Kane J, et al - Equine Vet J Suppl 31(1999), 201

• Stem cell therapy in a caprine model of osteoarthritis

  Murphy JM, Fink DJ, Hunziker EB, Barry FP - Arthritis Rheum 48(12) (2003), 3464-74

• Stem cells in the umbilical cord

  Weiss ML, Troyer DL - Stem Cell Rev 2(2) (2006), 155-62

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• Stem cells in veterinary medicine – attempts at regenerating equine tendon after injury

  Richardson LE, Dudhia J, Clegg PD, and Smith RKW - Trends Biotechnology 25 (2007), 409-416

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• Stem cells: classifications, controversies, and clinical applications

  Fortier LA - Vet Surg 34(5) (2005), 415-23

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• Successful engraftment of cultured autologous mesenchymal stem cells in a surgically repaired soft palate defect in an adult horse

  Carstanjen B, Desbois C, Hekmati M, Behr L - Can J Vet Re 70(2) (2006), 143-7

• Superficial digital flexor tendonitis in the horse

  Dowling BA, Dart AJ, Hodgson DR, et al - Equine Vet J 2000, 32, 369

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• Tenocyte response to cyclical strain and transforming growth factor beta is dependent upon age and site of origin

  Goodman SA, May SA, Heinegard D, Smith RK - Biorheology 41(5) (2004), 613-28

• Tenomodulin is necessary for tenocyte proliferation and tendon maturation

  Docheva D, Hunziker EB, Fassler R, Brandau O - Mol Cell Biol 25(2) (2005), 699-705

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• The effect of autologous mesenchymal stem cells on the biomechanics and histology of gel-collagen sponge constructs used for rabbit patellar tendon repair

  Juncosa-Melvin N, Boivin GP, Gooch C, Galloway MT, West JR, Dunn MG, Butler DL - Tissue Eng 12(2) (2005) 369-79

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• The pathobiology and repair of tendon and ligament injury

  Goodship AE, Birch HL, Wilson AM - Vet Clin North Am Equine Pract 10 (1994), 323

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• The relationship between mechanical work and energy expenditure of locomotion in horses

  Minetti AE, Ardigo LP, Reinach E, Saibene F - J Exp Biol 202 (1999), 2329-2338

• The value of ultrasonography in monitoring tendon health in racehorses in training.

  Davis CS, Ely ER, Verheyen KLP, Price JS, Wood JLN, Smith RKW - Proc of European Society of Veterinary Orthopaedics and Traumatology, Munich (2006)

• Tissue engineering of ligaments by human bone marrow stromal cells in a liquid fibrin matrix: histological, biomechanical, and molecular biological results of a study with immunodeficient rats

  Hankemeier S, van Greinsven M, Hurschler C, Westdoerp J, Jagodzinski M, Bosch U, Krettek C, Zeichen J - Proceeedings of the 51st Orthopaedic Research Society Meeting, 157 (2005)

• Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/periosteum- and fat-derived cells

  Park J, Gelse K, Frank S, von der Mark K, Aigner T, Schneider H - J Gene Med 8(1) (2006), 112-25

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• Use of mesenchymal stem cells in a collagen matrix for Achilles tendon repair

  Young RG, Butler DL, Weber W, Caplan AI, Gordon SL, Fink DJ - J Orthop Res 16(4) (1998), 406-13

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• Results of treatment of bone marrow derived mesenchymal stem cell therapy.

  Professor Roger K.W. Smith MA VetMB PhD DEO DipECVS MRCVS
  Dept. of Veterinary Clinical Sciences, The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Herts. AL9 7TA. UK

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• Isolation and implantation of autologous equine mesenchymal stem cells from bone marrow into the superficial digital flexor tendon as a potential novel treatment

  Smith RKW, Korda M, Blunn GW, Goodship AE - Equine Veterinary Journal (2003) 35 (1) 99-102

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• Implantation of bone marrow-derived mesenchymal stem cells demonstrates improved outcome in horses with overstrain injury of the superficial digital flexor tendon

  Godwin EE, Young NJ, Dudhia J, Beamish IC, Smith RKW

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