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Pall's Acelere™ f PRP system, offered exclusively by VetCell, uses filter-based technology to
provide equine veterinary surgeons with a quick and easy way of obtaining autologous platelet
rich plasma in the field or the clinic.
The Acelere™ f PRP System
- concentrates platelets
- provides growth factors which accelerate bone and soft tissue healing
- has been optimised for equine platelet enrichment
- can be carried out in the field using a simple disposable kit
PRP
Platelet Rich Plasma (PRP) is a component of blood in which the platelets are concentrated in a limited volume
of plasma. Platelets contain many growth factors that enhance wound healing and help to induce tissue regeneration.
Once platelets have adhered to injured vessels they release granules to start the clotting process. From this
network the platelets then release many growth factors inside the wound, of which PDGF, IGF and TGF-β play the
most important roles. PDGF is an activator of collagenase, which promotes the strength of the healed tissue and
TGF-β activates fibroblasts to form procollagen, which results in deposition of collagen within the wound.
PRP is used to promote wound, bone and ligament/tendon repair. In wounds it accelerates epithelial differentiation
and produces well organized tissue to enhance wound healing, especially in problematic lower limb injuries.
Histological and histomorphometric evaluation has shown it to enhance early bone healing. PRP therapy has also been
shown to enhance the healing response and the quality of repair in treatment of tendonitis and suspensory ligament
desmitis.
fPRP
One of the practical limiting factors in the use of autologous PRP has been the requirement for laboratory facilities
to obtain suitable preparations. VetCell, in collaboration with Pall Corporation, the largest filtration, separations
and purifications company in the world, has developed a closed filtered PRP system which utilises a simple disposable
kit to obtain autologous PRP in the clinic or in the field. Key to the success of this system are the Acelere™ mixed
mode column and the proprietary processing solutions which have been optimised specifically to trap equine platelets.
Importantly the Acelere™ fPRP system eliminates concerns about immunogenic reactions and minimises the chances of
infection or disease transmission as the PRP is autologous and is generated in a closed system.
Procedure
Harvesting the fPRP is a very straightforward procedure taking approximately 10 minutes. Venous blood is taken and
mixed with a capture solution in the collection bag before being passed through Pall's Acelere™ mixed mode column
where platelets are captured. Back-flushing the harvest solution through the column recovers the fPRP into a syringe.
Gel formation and platelet activation can be achieved by combining the fPRP with Thrombin. The procedure requires no
power source or specialist equipment.
Click here for details of how to use the system.